Mineralocorticoid receptor blockade for renoprotection
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity.
Recent studies from our laboratory have shown that the mineralocorticoid receptor (MR) blockade with spironolactone (Sp) prevented renal dysfunction and reduced renal injury in both acute and chronic cyclosporine (CsA) nephrotoxicity. This study was designed to evaluate whether Sp administration reduces functional and structural renal damage associated in the setting of preexisting chronic CsA ...
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Mineralocorticoid receptor blockers (MRBs) have proven highly successful in the treatment of congestive heart failure and resistant hypertension. In contrast, their use in chronic kidney disease (CKD) has lagged due to the concern of hyperkalemia and, possibly, because of the incorrect assumption that traditional therapy with angiotensin-converting enzyme inhibitors and/or angiotensin receptor ...
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Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. Previous studies have shown that mineralocorticoid receptors (MRs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. Moreover, we found no studie...
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Mineralocorticoid receptor blockade (MRB) has been shown to improve survival and reduce hospitalizations for heart failure (HF) in patients with chronic severe HF (New York Heart Association class III to IV) because of systolic left ventricular dysfunction1 and in patients with myocardial infarction complicated by systolic left ventricular dysfunction and HF.2 The role of MRB in patients with m...
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Fischer-344 (F344) rats exhibit proteinuria and insulin resistance in the absence of hypertension as they age. We determined the effects of long-term (1 yr) treatment with the angiotensin (ANG) II type 1 (AT(1)) receptor blocker L-158,809 on plasma and urinary ANG peptide levels, systolic blood pressure (SBP), and indexes of glucose metabolism in 15-mo-old male F344 rats. Young rats at 3 mo of ...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2018
ISSN: 2211-9140
DOI: 10.23876/j.krcp.2018.37.3.183